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In the current review, we sought to discover a small molecule that might be utilised to take care of skeletal muscle atrophy. The strategy that we took was unbiased and fundamentally unique from classic drug discovery techniques mainly because it relied on systemic effects of small molecules rather than predefined molecular targets or pathways. Int

Rapamycin, also known as sirolimus, can be a natural product with potent antifungal and immunosuppressive actions. It forms a complex Using the immunophilin FK506-binding protein twelve (FKBP12), which then stabilizes the raptor-mTOR association and inhibits the kinase exercise of mTOR32. As an inhibitor of mTOR, rapamycin is widely described from